A recent study published in the Journal of Cosmetic Dermatology has highlighted a potential association between n-3 fatty acids (FAs) and a decreased risk of developing psoriasis.
The research aimed to explore the causal relationship between levels of fatty acids and psoriasis using a Mendelian randomization approach. Data sourced from genome-wide association studies were employed to analyze multiple types of fatty acids. The results of the Mendelian analysis revealed a promising causal link between n-3 fatty acid levels and a lower risk of psoriasis, supported by a significant odds ratio and confidence interval (OR/95% CI: 0.998/(0.997, 0.999), P-value: 2.479 × 10^-4).
Further analyses verified the consistency of these findings and ruled out horizontal pleiotropy, indicating that the observed association was not influenced by other factors. However, the study did not identify any causal effects from other types of fatty acids on psoriasis.
The authors emphasized the need for well-designed prospective studies and large-scale, multicenter randomized controlled trials to validate these findings conclusively.
